Coronary Vasodilating Effect of Some Chromanone Derivatives

Coronary vasodilating effect of some chromanone derivatives.

Coronary vasodilating activity of chromone derivatives has been reported.2) It is worth examining if chromanone derivatives have a coronary vasodilating effect, since they are chemically related to chromone. In the present study the effects of some benzylidene chromanones and its related compounds on coronary blood flow and myocardial oxygen consumption in anesthetized dogs and also on the oxyg...

Benzylpiperazine derivatives. IV. Syntheses and cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazine derivatives.

A considerable body of literature exists on the biological activity of compounds containing the piperazine moiety. In the field of 1-benzyl-4-diphenylmethylpiperazines, antihistaminics,2-4) tranquillizers,5,6) and vasodilators7) have been reported. Some of them, such as buclizine (1), meclizine (2) and medibazine (3), have been used clinically. More recently, 1-diphenylmethyl-4-(4-hydroxybenzyl...

The effect of some cystine derivatives on catalase activity.

The decreased liver catalase activity of animals bearing tumors is well known (17, 18). However, various explanations of this effect have been of fered. One of these, as exemplified by the studies of Nakahara et al. (Il, 12, 23-26), postulates that tumors release a factor designated as toxohormone, which exerts its effect on liver catalase. A similar view is also taken by other investigators (1...

The effect of some -aminocaproic acid derivatives on platelet responses

-Aminocaproic acid (EACA) is a synthetic low molecular drug with antifibrinolytic activity. However, treatment with this drug can be incidentally associated with an increased thrombotic tendency. The aim of the present work was to test synthetic EACA derivatives for their antiplatelet activities. We investigated the effect of three EACA derivatives with antifibrinolytic activity: I. -aminocapro...

Some derivatives of dibenzothiophene.